Andrew Peterson, Senior Director of Molecular Biology Genentech, USA called, hyperglycemia or a condition in which blood sugar rises to be the main trigger for the emergence of complications of microvascular diabetes or triggers of microrovascular diabetes.
In a Public Seminar entitled “The Power of Advance Genomics” at Eijkman Institute, Jakarta on Wednesday (14/2/2018), he said, people with type 1 diabetes tend to have a potential microvascular complications.
“Persistent hyperglycaemia affects the decreased ability of blood vessels, and the occurrence of the proteins that are involved in the blood vessels is weakened and fragile, causing small blood vessels to become blocked,” he said.
On the occasion, Andrew also described the results of research he did about the link of genes to the development of complications of microvascular diabetes in India.
“The research I’m working on, took a sample of 9,000 diabetes patients with genetic variations in India. The problem is, we understand but do not know how these microvascular complications occur, “said Andrew.
Genetic factors, called Andrew, do not play a role in the formation of microvascular complications. Microvascular diabetes complications caused by genetic factors are quite rare.
“It rarely happens. But genetic influences persist. That is why, people with similar conditions of hyperglycemia will experience different risks of microvascular complications, “said Andrew.
If it attacks the eye, microvascular complications in diabetes will trigger blindness. This is called retinopathy. If complications of microvascular diabetes occur in the kidneys, the individual will be affected by kidney failure. This is called nephropahy.
Meanwhile, if diabetic microvascular complications occur in the nerves, it will trigger impotence. The term used is neuropathy.
Diabetes that is already in the stage of microvascular complications also causes an infection in the legs. Next. the decayed legs of the patient should be cut off. This amputation to prevent the spread of infection.