Tooth decay is one of the most painful and very disturbing problems. When our teeth are hollow, broken, or cracked, there is actually abrupt teeth erosion from time to time. To handle this problem, dental experts generally recommend patching or removing damaged teeth so that germs and bacteria do not enter the blood vessels and spread throughout the body tissues. Related to the treatment of cavities, US scientists have found a method that can encourage the tooth enamel to grow back, ie through the peptide. Also Read: Mini-Size, Dental Sensor This is your Food Agenda In the findings published in the journal ACS Biomaterials Science & Engineering, Monday (9/4/2018), researchers explain tooth enamel produced by ameloblast cells. These cells produce amelogenin proteins that play an important role in the formation of enamel when the teeth are still in the gums. However, when the enamel formation process is complete and the tooth grows, the ameloblast cells die. “Bacteria metabolize the sugar and fermented carbohydrates into acid and resulted in the process of demineralization (cessation of the mineralization process) tooth enamel that makes the tooth damaged,” said dentist Sami Dogan Science told Science Alert on Monday (4/16/2018). Dental experts explain, teeth can actually be recrystallized with the help of saliva, fluoride toothpaste, and drinking water additives. However, when there is a cavity or damage in the tooth, the doctor will patch it. From here, scientists think to make something that is developed based on amelogenin protein. They eventually designed peptides based on amelogenin protein as the active ingredient. Peptide bonds are short-chain links of amino acids, which include incomplete proteins, because they have little amino acid content. Trials were performed in the laboratory using a damaged tooth sample. When the peptide is applied to a tooth sample, the team finds a new mineral layer appearing on the damaged tooth area. “Remineralization (redevelopment of dental mineral, red) guided peptide is a new method of healthy treatment,” said Mehmet Sarikaya.
Despite succeeding in growing enamel on the damaged dental samples in the laboratory, trials to use peptide design on living human teeth have not been performed. Until then, researchers believe this method can be marketed in the form of pasta or gel to protect the teeth of the hole.