Cystic fibrosis, a genetically inherited disease of the exocrine glands in man, has no known counterpart in animals. The symptoms in man produced by mucous obstructing the lungs, pancreas and liver have been described. The signs, symptoms and course of an analogous disease in animals have been predicted. If an analogous disease in animals can be discovered, it is anticipated that it will make possible significant advances in the study of the normal and pathological physiology of the abnormal exocrine glands and will lead to a means of controlling the human disease.


Uncontrolled, progressive fibrosis is a driving factor in or hallmark of many debilitating disease states, afflicting millions of individuals in the United States and worldwide. Fibrosis-related diseases can affect organs including the kidney, liver, lungs, skin, and eye, leading to organ dysfunction and failure, and potentially death.

While the underlying pathophysiology of fibrosis is complex, research continues to enhance our understanding of this disease process. Key components of one of the primary biological pathway are known, as represented below; however, there is a pressing need to identify and develop new therapies against additional novel targets and pathways.

fibrosisThe most common sources of added sugars include soft drinks, cakes, pies, chocolate, fruit drinks and desserts. Just a single can of cola can contain up to 7 tsps of added sugar, while an average-sized chocolate bar can contain up to 6 tsps.



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